SH2 domains, and other binding domains, have been used in protein engineering to create protein assemblies. Protein assemblies are formed when several proteins bind to one another …

In this review, we recapitulate the current knowledge about the structural, folding stability, and binding properties of SH2 domains and their roles in molecular pathways and pathogenesis. …

3 days ago · Src-homology 2 (SH2) domains are modules of approximately 100 amino acids that bind to specific phospho (pY)-containing peptide motifs. Conventional SH2 domains have a …

Jun 16, 2025 · In the immune system, SH2 domains are involved in how cells respond to cytokines, which are molecules that signal inflammation and immune activation. Proteins like …

This volume looks at the latest methods used to study and modulate the biological function and mechanisms of SH2 domains. The chapters in this book are organized into five parts.

Dec 15, 2022 · In this review, we recapitulate the current knowledge about the structural, folding stability, and binding properties of SH2 domains and their roles in molecular pathways and …

Feb 15, 2024 · The SH2 domain of SOCS2 serves as a substrate receptor, which binds pTyr on cytokine receptors and other proteins, triggering their ubiquitylation and degradation.

The SH2 domain is defined as a protein module that forms a pocket for binding phosphorylated tyrosine residues, facilitating interactions with specific amino acid sequences downstream, and …

Activated JAK kinases then phosphorylate tyrosine residues on the cytokine receptors, providing docking sites for SH2 domain-containing intracellular signaling proteins.

Members of the SH2 domain family modulate signal transduction by binding to short peptides containing phosphorylated tyrosines. Each domain displays a distinct preference for the …