Monoclonal antibody - Wikipedia
A monoclonal antibody (mAb, more rarely called moAb) is an antibody produced from a cell lineage made by cloning a unique white blood cell. All subsequent antibodies derived this way …
Monoclonal Antibodies: Purpose, Risks & Results
Dec 10, 2025 · Monoclonal antibodies can treat autoimmune conditions, cancers and other diseases by working with your immune system.
Monoclonal Antibodies and Their Side Effects | American ...
Bevacizumab (Avastin) is an mAb that targets a protein called VEGF that affects tumor blood vessel growth. It can cause side effects such as high blood pressure, bleeding, poor wound …
What are Monoclonal Antibodies and how do they work? - Drugs.com
Jun 3, 2025 · The mAb (ibritumomab) delivers a radioactive substance (Yttrium-90) directly to cancer cells. Another example is Kadcyla, an mAb that is attached to a chemotherapy drug.
Monoclonal antibody drugs for cancer: How they work
Monoclonal antibody drugs are treatments that enlist your body's germ-fighting immune system against diseases, including cancer. If your health care provider recommends a monoclonal …
The pharmacology and therapeutic applications of monoclonal ...
The majority of mAb therapeutics are for oncological and immunological/infectious diseases, but these are expanding into other disease areas. Over 100 monoclonal antibodies are in …
Overview of therapeutic monoclonal antibodies - UpToDate
Aug 18, 2025 · According to the World Health Organization (WHO), which is responsible for therapeutic mAb nomenclature, over 800 mAb names have been provided [1]. (See 'Naming …
Why mAbs Matter | Quality Matters | U.S. Pharmacopeia Blog
Feb 6, 2025 · FDA-approved mAb treatments have been available since the late 1980s. Monoclonal antibody drugs have proven to be more successful at treating certain diseases, …
Monoclonal Antibodies: How They Work, Uses, Side Effects
Apr 19, 2023 · A monoclonal antibody (mAb) is a type of immune protein produced in a lab that binds to a specific protein on a cell called an antigen. As with naturally occurring antibodies, …
Monoclonal Antibodies - Smithsonian Institution
The first mAb drug approved by the FDA was Orthoclone, in June 1986. The drug prevented kidney rejection in transplant patients. The mAb worked by binding to and disrupting the …