Because CD3 is required for T-cell activation, drugs (often monoclonal antibodies) that target it are being investigated as immunosuppressant therapies (e.g., otelixizumab, teplizumab) for …

Aug 4, 2025 · CD3 (Cluster of Differentiation 3) is a protein complex found on the surface of T cells. It acts as a universal marker for T cells, used to identify and count T cells.

CD3 is part of the T-cell receptor (TCR) complex, which is essential for T-cell activation in response to antigens. When T-cells recognize a foreign pathogen, CD3 initiates a cascade of …

CD3 is a multimeric protein complex comprising three different subunits: CD3δε, CD3γε, and CD3ζζ dimers. Homologous CD3δε and CD3γε are heterodimers with single extracellular …

This mini-review explains the structure of CD3, the genes involved in its expression, its function and the signal transduction pathways mediated by CD3 complex.

Nov 14, 2025 · The CD3 complex acts as the signal transducer, translating external recognition by the TCR into internal cellular action. The complex is composed of multiple protein chains, …

Mar 18, 2022 · CD3 is a cell surface complex composed of 4 distinct subunits; these subunits are chains of integral membrane glycoproteins that associate with T cell antigen receptor (TCR) …

Jan 2, 2026 · CD3 (Cluster of Differentiation 3) is a multi-subunit protein complex expressed exclusively on the surface of T cells. It is an integral component of the T cell receptor (TCR) …

Jun 7, 2024 · CD3 is a protein complex found on the surface of T cells, a type of white blood cell that is central to the immune response. The CD3 complex is composed of several subunits: …

Anti-CD3 antibodies act as potent immunosuppressive agents by modulating the CD3/T-cell receptor (TCR) complex. They have been used in patients to prevent short term allograft …