Researchers at the Weill Institute for Cell and Molecular Biology have uncovered new evidence that two major types of gene-controlling DNA sequences, promoters and enhancers, operate with a shared ...
The human genome harbours a dizzying array of regulatory sequences, such as enhancers with a priori unpredictable, promiscuous and context-dependent behaviour. More than 90% of disease-associated ...
Understanding human biology requires more than mapping our genes—we must also understand how gene expression is regulated to guide healthy development, growth, and maintenance of our body systems over ...
Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers are ...
Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called ...
Despite our knowledge of the complete genome sequences of several dozen species and high-quality annotation of the protein coding genes, the identification of active regulatory elements remains ...
A good storyteller knows exactly which anecdotes will bring his stories’ characters to life. By telling the right story at the right time, our genome even manages to give rise to hundreds of different ...
In a scientific feat that broadens our knowledge of genetic changes that shape brain development or lead to psychiatric disorders, a team of researchers combined high-throughput experiments and ...
Each one of our cells has the same 22,000 or so genes in its genome, but each uses different combinations of those same genes, turning them on and off as their role and situation demand. It is these ...
About 700 million years ago, sponges branched off from all other animals on the tree of life. Despite this evolutionary distance, sponges share a form of gene regulation with much more complex species ...
The images show the abdomen of flies in which a specific enhancer region has been modified. Depending on how much and which part of the region is modified, different areas of the pigment pattern ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results