The human genome harbours a dizzying array of regulatory sequences, such as enhancers with a priori unpredictable, promiscuous and context-dependent behaviour. More than 90% of disease-associated ...
Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called enhancers, was thought to have its own place on the DNA. Different enhancers are ...
A good storyteller knows exactly which anecdotes will bring his stories’ characters to life. By telling the right story at the right time, our genome even manages to give rise to hundreds of different ...
Understanding human biology requires more than mapping our genes—we must also understand how gene expression is regulated to guide healthy development, growth, and maintenance of our body systems over ...
Some sequences in the genome cause genes to be switched on or off. Until now, each of these gene switches, or so-called ...
Only about two percent of the mammalian genome contains blueprints for proteins, while some of the remaining DNA is able to control the activity of these genes. Hereditary diseases can therefore arise ...
In each cell, thousands of regulatory regions control which genes are active at any time. Scientists have now developed a method that reliably detects these regions and measures their activity. In ...
In a scientific feat that broadens our knowledge of genetic changes that shape brain development or lead to psychiatric disorders, a team of researchers combined high-throughput experiments and ...
“A coordinated regulatory dance”: Levine lab identifies new elements involved in genome organization
Over the course of three months, Professor Michael Levine’s lab at the Department of Molecular Biology and the Lewis-Sigler Institute for Integrative Genomics have published two papers elucidating the ...
About 700 million years ago, sponges branched off from all other animals on the tree of life. Despite this evolutionary distance, sponges share a form of gene regulation with much more complex species ...
The images show the abdomen of flies in which a specific enhancer region has been modified. Depending on how much and which part of the region is modified, different areas of the pigment pattern ...
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