Scientists show that neutralizing liver-derived ApoE protein reverses age-related delays in bone fracture healing ...

Endothelial-to-Osteoblast Conversion (EC-to-OSB) regulates bone formation and homeostasis via the Kindlin-2/Piezo1/TGFβ/Runx2 axis. Reduced Kindlin-2 in endothelial ...

Wif1 overexpression accelerated osteogenic differentiation by activating genes related to late-stage osteogenic differentiation and mitophagy processes. Moreover administering Wif1-overexpressing ...

Osteoblasts act in a group to make bone over the course of several months. However, how osteoblasts cooperate with each other in vivo is still unknown. Now, researchers at Osaka University established ...

Osteoporosis or the weakening of bones makes the aging population vulnerable to fractures and a decreased quality of life. The parathyroid hormone (PTH)-derived peptide -- teriparatide has ...

Osteoporosis—weakening of the bones with age—affects millions worldwide, and this figure is increasing annually as the global population ages. It is associated with the aging, or "senescence," of bone ...

An attractive strategy for treating osteoporosis has been to develop drugs that will bind to receptors on osteoprogenitor cells and coax the cells to differentiate into osteoblasts instead of ...

Stem cells and progenitor cells reside in various tissues of the body and are capable of generating daughter cells of different lineages. Mesenchymal stem cells (MSCs) are multipotent stromal cells ...

Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements. The structural integrity of bones has been attributed to bone remodeling-aa ...