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Web-based tool improves CRISPR accuracy by identifying off-target effects across genetic variations
Genome editing technologies like CRISPR-Cas9 have transformed biology, medicine, and agriculture, but concerns remain about unintended edits at off-target DNA sites. These off-target effects can cause ...
Researchers introduce Variant-aware Cas-OFFinder, a web-based tool that improves CRISPR off-target predictions by incorporating individual genetic differences. By reconstructing allele-specific ...
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