Flap endonuclease-1 (FEN-1), a structure specific nuclease, is an essential enzyme for eukaryotic DNA replication and repair. The crystal structure of FEN-1 from Methanococcus jannaschii, determined ...
Mechanisms for replicating DNA / G.S. Brush and T.J. Kelly -- Origins of DNA replication / M.L. DePamphilis -- Roles of transcription factors in DNA replication / P.C. van der Vliet -- Roles of ...
Primases are essential components of the DNA replication apparatus in every organism. They catalyze the synthesis of oligoribonucleotides on single-stranded DNA, which subsequently serve as primers ...
A new study published in Nature Structural & Molecular Biology reveals how the fundamental enzyme called DNA polymerase delta operates during DNA replication, making a copy of the genetic code that ...
Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental ...
MSK researchers are shedding new light on G-quadruplexes, a type of secondary DNA structure that can cause DNA replication to stall. The structures are a potential therapeutic target in cancer. Image ...
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