The secret to the naked mole-rats' extraordinarily long life may lie in subtle changes to just four amino acids, researchers report. According to a new study, evolutionary mutations in cGAS – an ...
When the rodent cGAS enzyme was inserted into human and mouse cells in the laboratory, the researchers observed that it significantly enhanced the cells' ability to repair DNA and in turn reduced the ...
A naked mole rat with its head raised and nose in the air. Long live the naked mole rat. These wrinkly critters live about 37 years, thanks in part to an enzyme that helps regulate DNA repair. Credit: ...
cGAS-STING signaling exerts antitumor functions in cancer cells in an autonomous and non-autonomous manner. On the one hand, OIS secretes SASP in response to oncogenic stimuli to prevent cell ...
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